Identify the cell organelle that has a role in detoxifying harmful substances.

The smooth endoplasmic reticulum (SER) is the correct answer because it plays a crucial role in the detoxification of harmful substances within the cell. This organelle is involved in the synthesis of lipids and the metabolism of carbohydrates, but one of its primary functions is to help process and remove toxins, such as drugs and alcohol.

The smooth endoplasmic reticulum achieves this detoxification by modifying these potentially harmful substances into less toxic compounds that can be easily excreted from the cell or the body. This process is vital for maintaining cellular health and ensuring that the harmful effects of toxins are minimized.

In contrast, the other organelles have different primary functions. The Golgi apparatus is mainly responsible for modifying, packaging, and distributing proteins and lipids within the cell. Mitochondria are known as the powerhouses of the cell, as they produce ATP through cellular respiration. Lysosomes contain enzymes that break down waste materials and cellular debris, but they are not specifically dedicated to detoxifying substances in the way the smooth endoplasmic reticulum is.